Background The Mulligan method of manual therapy advocates the use of ‘mobilization with movement (MWM)’ techniques to effectively manage peripheral joint ‘positional fault’ dysfunctions. Objectives To provide an updated evidence-based systematic review and meta-analysis regarding the effectiveness of MWM techniques. Data sources PubMed, EBSCOhost, PEDro, Cochrane Library and Google Scholar between 1st August 2008-31st August 2017. Study selection Two reviewers applied the population intervention comparison outcome (PICO) question to screen the studies for this review. Only RCTs/CCTs were included. Data extraction Information on study design, subjects, intervention, outcome measures and efficacy results were extracted. Methodological quality was independently assessed by two reviewers using the PEDro Scale. Data synthesis 16 studies with 576 participants were included in 4 separate meta-analyses for pain and disability. The I2 index assessed the heterogeneity between studies. Results MWMs have demonstrated statistically significant improvements against placebo, passive and control intervention techniques for pain [mean difference(95%CI): −16.12 (-19.77, −12.48) & I2 = 72%] and disability [mean difference(95%CI): −17.51 (−22.84, −12.19) & I2 = 88%] or against another manual therapy treatment [pain mean difference(95%CI): −10.43(−11.38, −9.48) & I2 = 0%], however not against another manual therapy treatment for disability. The clinical significance of the pooled differences was compared against Minimal Clinically Important Difference values.